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Post by geronimo on Mar 13, 2021 1:42:22 GMT
Enlivex is a very interesting Israeli company. Their cell therapy allocetra is effective against cytokine storm. The big money is of course as a treatment for sepsis, but they are quickly advancing in trials for covid as well and guide that they could be granted emergency use status as early as this quarter in Europe. The technology is simple, elegant, and brilliant. What they do is produce a culture of early apoptotic cells (cells that are programmed to commit suicide) and transfuse them into a patient. When the bodies' macrophages eat apoptotic cells, the macrophages subsequently send out calming signals; this stops cytokine storm dead in its tracks. The preliminary data looks near miraculous, 0% mortality and patients who typically stay in the hospital for over a month are going home in a week. Macrophages can be reprogrammed similarly to become more active, this allows them to potentially treat a whole host of other indications such as cancer. They have some interesting pre-clinical studies where they use allocetra as a bolt-on treatment to PLD-1 kind of like oncosec does with very good results. The cancer stuff is a long way off, but interesting none the less, as it really shows how innovative and paradigm changing of a technology they have with macrophage reprogramming. The company is well funded 90M and low burn rate as well as low float. Market cap is sitting at a paltry quarter billion. Their cell product is derived from blood donations. When blood is donated they spin out the WBC and typically throw those away, instead Enlivex generates allocetra from that former waste product.
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Post by JHam on Mar 13, 2021 2:18:27 GMT
Enlivex is a very interesting Israeli company. Their cell therapy allocetra is effective against cytokine storm. The big money is of course as a treatment for sepsis, but they are quickly advancing in trials for covid as well and guide that they could be granted emergency use status as early as this quarter in Europe. The technology is simple, elegant, and brilliant. What they do is produce a culture of early apoptotic cells (cells that are programmed to commit suicide) and transfuse them into a patient. When the bodies' macrophages eat apoptotic cells, the macrophages subsequently send out calming signals; this stops cytokine storm dead in its tracks. The preliminary data looks near miraculous, 0% mortality and patients who typically stay in the hospital for over a month are going home in a week. Macrophages can be reprogrammed similarly to become more active, this allows them to potentially treat a whole host of other indications such as cancer. They have some interesting pre-clinical studies where they use allocetra as a bolt-on treatment to PLD-1 kind of like oncosec does with very good results. The cancer stuff is a long way off, but interesting none the less, as it really shows how innovative and paradigm changing of a technology they have with macrophage reprogramming. The company is well funded 90M and low burn rate as well as low float. Market cap is sitting at a paltry quarter billion. Their cell product is derived from blood donations. When blood is donated they spin out the WBC and typically throw those away, instead Enlivex generates allocetra from that former waste product. It sounds very cool. For those interested the ticker is ENLV, $262M market cap, 9.24M float. I'm always a little hesitant with Israeli companies based on past experiences, but I'll look into this one a bit more.
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Post by magnus123 on Mar 13, 2021 13:22:17 GMT
Never invest in israeli biotech. I had to learn that in the hard way...
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Post by geronimo on Mar 15, 2021 3:26:54 GMT
wow sounds like you guys got burned bad!!
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Post by geronimo on May 3, 2021 20:34:22 GMT
news is expected here this week...rumor has it that india has agreed to purchase ENLVs therapeutic allocetra to treat critical cases of covid.
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Post by geronimo on Jun 19, 2021 15:48:10 GMT
been a very disappointing hold with no news, despite so many promising meetings with countries desperate for a severe covid treatment. might be waiting till sepsis interim data till we see sp rise.
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Post by magnus123 on Jun 20, 2021 14:52:18 GMT
been a very disappointing hold with no news, despite so many promising meetings with countries desperate for a severe covid treatment. might be waiting till sepsis interim data till we see sp rise. When will they announce sepsis data?
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Post by geronimo on Aug 31, 2021 20:51:03 GMT
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Post by geronimo on Mar 20, 2023 21:55:19 GMT
ENLV has an interesting cancer trial ongoing and just received clearance from DMSB to continue with escalating dose. Interim sepsis data likely to be revealed soon as well.
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Post by geronimo on Apr 3, 2024 18:54:06 GMT
ENLV sepsis results should be forthcoming as they are guided for release this month. Stock has been climbing last several weeks no doubt from speculation.
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